Significance of P16 hypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (Gruppo Oncologico dell’Italia Meridionale) prospective study
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چکیده
Significance of P16 hypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (Gruppo Oncologico dell’Italia Meridionale) prospective study V. Agnese, S. Corsale, V. Calò, C. Augello, L. Bruno, D. Calcara, A. Crosta, V. Rodolico, G. Rinaldi, G. Cicero, F. Latteri, A. Agrusa, V. Morello, V. Adamo, G. Altavilla, G. Di Fede, E. Fiorentino, N. Grassi, M. A. Latteri, M. R. Valerio, R. M. Tomasino, G. Colucci, V. Bazan & A. Russo* Section of Medical Oncology, Section of Surgical Oncology, Department of Surgical and Oncology, Section of General Surgery, Department of Human Pathology, Università di Palermo; Unit of Medical Oncology, A.O.Universitaria Policlinico ‘G.Martino’, Università di Messina; Division of Medical Oncology, National Institute of Oncology, Bari, Italy; Department of Medical Oncology, University of Messina, Italy
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Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study.
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Gastric Cancer (GC) is the second most common cancer in the world and a leading cause of cancer-related mortality. Methylation of promoter CpG islands (CGIs) belonging to tumor suppressor genes causes transcriptional silencing of their corresponding genes leading to carcinogenesis and other disorders. Adenomatous Polyposis Coli (APC) a tumor suppressor gene is inactivated by methylation of prom...
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Hypermethylation of CpG islands located in the promoter regions of genes is a major event in the development of the majority of cancer types, due to the subsequent aberrant silencing of important tumor suppressor genes. KLOTHO; a novel gene associated primarily with suppressing senescence has been shown to contribute to tumorigenesis as a result of its impaired function. Recently the relevance ...
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PURPOSE Surgical margin status is reported to be a relevant prognostic factor in head and neck squamous cell carcinoma (HNSCC), associated with a high risk of local recurrence. This study examines whether gene-promoter hypermethylation could be detected in HNSCC surgical margins with no histologic evidence of malignancy, and if so, whether it reflects epigenetic events of primary tumors. EXPE...
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